Toward a numerical deshaker for PFS

The Planetary Fourier Spectrometer (PFS) onboard Mars Express (MEx) is the instrument with the highest spectral resolution observing Mars from orbit since January 2004. It permits studying the atmospheric structure, major and minor compounds. The present time version of the calibration is limited by the effects of mechanical vibration, currently not corrected. We proposed here a new approach to correct for the vibrations based on semi-blind deconvolution of the measurements. This new approach shows that a correction can be done efficiently with 85% reduction of the artefacts, in a equivalent manner to the stacking of 10 spectra. Our strategy is not fully automatic due to the dependence on some regularisation parameters. It may be applied on the complete PFS dataset, correcting the large-scale perturbation due to microvibrations for each spectrum independently. This approach is validated on actual PFS data of Short Wavelength Channel (SWC), perturbed by microvibrations. A coherence check can be performed and also validate our approach. Unfortunately, the coherence check can be done only on the first 310 orbits of MEx only, until the laser line has been switch off. More generally, this work may apply to numerically "deshake" Fourier Transform Spectrometer (FTS), widely used in space experiments or in the laboratory.Comment: 18 pages, 8 figures, submitted to Planetary and Space Scienc

ASSOCIATIONS OF POLYMORPHISMS IN CYTOKINE GENES WITH THE INFECTIOUS GENESIS Of RECCURENT MISCARRIAGE

The associations of polymorphisms in cytokine genes with the infectious form recurrent miscarriage were investigated. Have established, that at the women a genotype AA of a gene TNFA (rs1800629) and combination of genotypes *1/*1 genes IL1RN and GG of a gene IL6 (rs1800795) are involved in pathogenesis recurrent miscarriage

THE ASSOCIATION OF IMMUNE RESPONSE TO XENOAND ENDOBIOTIKS AND THEIRS BIOTRANSFORMATION ENZYME GENE POLYMORPHISM WITH CONGENITAL MALFORMATIONS OF THE FETUS

The correlation between immune response to benzo(a)pyrene and progesterone in combination with detoxification enzyme gene polymorphism (CYPIA2*1F and GSTTI) and the occurrence of congenital malformations of the fetus was revealed. It is shown that at high ratio of IgA-antibodies to benzo(a)pyrene and to progesterone in conjunction with the mutant allele of the gene CYPIA2*1F and the deletion genotype of the gene GSTTI chance of the reproductive pathology developing increases to 41 times

An analysis-ready and quality controlled resource for pediatric brain white-matter research

We created a set of resources to enable research based on openly-available diffusion MRI (dMRI) data from the Healthy Brain Network (HBN) study. First, we curated the HBN dMRI data (N = 2747) into the Brain Imaging Data Structure and preprocessed it according to best-practices, including denoising and correcting for motion effects, susceptibility-related distortions, and eddy currents. Preprocessed, analysis-ready data was made openly available. Data quality plays a key role in the analysis of dMRI. To optimize QC and scale it to this large dataset, we trained a neural network through the combination of a small data subset scored by experts and a larger set scored by community scientists. The network performs QC highly concordant with that of experts on a held out set (ROC-AUC = 0.947). A further analysis of the neural network demonstrates that it relies on image features with relevance to QC. Altogether, this work both delivers resources to advance transdiagnostic research in brain connectivity and pediatric mental health, and establishes a novel paradigm for automated QC of large datasets

CORRECT ALGORITHM OF ARVI TREATMENT IN PEDIATRIC PATIENTS

Acute respiratory infections (ARI) occupy the first place in morbidity among children and among adults for the past many decades. In General, the treatment is assigned to doctors on the basis of examination of the patient, in the absence of laboratory data on etiological characteristics of the infection. In such cases, the doctor cannot predict the nature of the disease and the risk of possible complications. This leads to prescription of unnecessary drugs. For the treatment of ARI in pediatric population currently there are a large number of drugs with a broad spectrum of antiviral action. Often at the same time 2-3 antiviral drugs are prescribed with different mechanisms of action. This contributes to excessive drug treatment, a very undesirable one in pediatric practice. To reduce the risk of excessive drug load, it is desirable to use one substance with a complex effect on various factors of infectious-inflammatory process

Inhaled corticosteroids in the treatment of croup in children

Respiratory diseases in children are socially significant due to their high prevalence, the associated morbidity, disability and large sums of public money spent on providing patients with medicines and skilled medical care [1, 2]

ANTITUSSIVE DRUGS IN CHILDREN’S PRACTICE

Adequate choice and use of antitussive therapy in pediatrics presupposes knowing at least the two key aspects: causes of cough and the specific mechanism of the cough reflex in children, as well as the mechanisms of action of antitussive drugs used. The need for the treatment of cough as such, that is, prescription of the so-called antitussive drugs, arises mainly in children with nonproductive, dry, persistent cough. Central antitussives suppress the function of the cough center in the medulla oblongata or other associated nerve centers of the brain. The antitussive drug butamirate, often used in children, selectively affects the cough center, does not cause respiratory depression, has an extremely low incidence of side effects, remains effective in prolonged therapy, and starts to exert its maximum effect after the first applicatio

Experimental characterization of vibration sources

Abstract—Mobility and impedance schemes are widely used in mechanical systems analysis to predict the effects of vibration sources on the system dynamics. This paper describes a systematic approach based on the mobility and impedance method for the characterization of vibration sources. The cases of elastic and rigid bodies are considered and analyzed. Guidelines for the design of the force and torque measurement systems are provided, together with different approaches for their metrological characterization. The characterization of a cryocooler for space-borne instrumentation is eventually shown as a case-study

Diagnosis and treatment of cough in children

Cough is one of the most common reasons for seeking medical care and may be one of the manifestations of the respiratory tract pathology and various extrapulmonary diseases. Given the diversity of causes of cough, the individualized approach to differential diagnosis and rational purpose of antitussive therapy is required. Agents of plant origin used in the treatment of cough, differ in composition, mechanism of action, forms of production; their modern production must be accompanied by strict control of collection, storage and processing of raw materials. The syrup Eucabal has an expectorant, anti-inflammatory, antioxidant and bactericidal activity by increasing the activity of ciliated epithelium of the mucous membranes of the respiratory tract, reducing hypersecretion, liquefying the phlegm and accelerating its evacuation